Krause Lab

University of Otago

Recent Publications

Scaletti, E., Luckner, S., and Krause, K.L. (2012) Structural Features and Kinetic Characterization of Alanine Racemase from Staphylococcus aureus (Mu50). Acta Crystallographica Section D. 68:82. PDF

Anthony, K., Strych, U., Yeung, K., Shoen, C., Perez, O., Krause, K.L., Cynamon, M., Aristoff, P., and Koski, R. (2011) New classes of alanine racemase inhibitors identified by high-throughput screening show antimicrobial activity against Mycobacterium tuberculosis. PLoS One. 6(5);e20374. PDF

Im, H., Sharpe, M., Strych, U., Davlieva, M., and Krause, K.L. (2011) The crystal structure of alanine racemase from Streptococcus pneumoniae, a target for structure-based drug design. BMC Microbiol. 11:116.

Couñago, R., Fleming, S., Mercer, A., and Krause, K.L. (2010) Crystallization and preliminary X-ray analysis of the chemokine-binding protein from orf virus (Poxviridae). Acta Crystallographica Section F. F66. PDF


Couñago, R., Davlieva, M., Strych, U., Hill, R., and Krause, K.L. (2009) Biochemical and structural characterization of alanine racemase from Bacillus anthracis (Ames). BMC Structural Biology. 9(53).

Chen, C., Krause, K.L., and Pettitt, B. (2008) Advantage of Being a Dimer for Serratia marcescens Endonuclease. J. Physical Chemistry B. 113(2);511-521. (Cover Art). PDF

Milligan, D., Tran, S., Strych, U., Cook, G., and Krause, K.L. (2007) The Alanine Racemase of Mycobacterium smegmatis is Essential for Growth in the Absence of D-Alanine. J. Bacteriol. 189(22);8381-8386. PDF


Strych, U., Davlieva, M., Longtin, J., Murphy, E., Im, H., Benedik, M., and Krause, K.L. (2007) Purification and preliminary crystallization of alanine racemase from Streptococcus pneumoniae. BMC Microbiology. 7(40). PDF


Weksberg, T., Lynch, G., Krause, K.L., and Pettitt, B. (2007) Molecular Dynamics Simulations of Trichomonas vaginalis Ferredoxin Show Loop-Cap Transition. Biophysical J. 92;3337-3345. PDF


Chen, C., Beck, B., Krause, K.L., Weksberg, T., and Pettitt, B. (2007) Effects of dimerization of Serratia marcescens endonuclease on water dynamics. Biopolymers. 85(3);241-252.

Hastings, J., and Krause, K.L. (2006) Luciferases and Light Emitting Accessory Proteins: Structural Biology. Nature Encyclopedia of Life Sciences. John Wiley & Sons, Ltd: Chichester.

Chen, C., Beck, B., Krause, K.L., and Pettitt, B. (2005) Solvent Participation in Serratia marcescens Endonuclease Complexes. Proteins: Structure, Function and Bioinformatics. 62(4);982-99.


Shelburne, S. 3rd, Visnegarwala, F., Adams, C., Krause, K.L., Hamill, R., and White, A. Jr. (2005) Unusual manifestations of disseminated Histoplasmosis in patients responding to antiretroviral therapy. Am J Med. 118;1038-1041.


LeMagueres, P., Im, H., Ebalunode, J., Strych, U., Benedik, M., Briggs, J., Kohn, H., and Krause, K.L. (2005) The 1.9 Å crystal structure of alanine racemase from Mycobacterium tuberculosis contains a conserved entryway into the active site. Biochemistry. 44;1471-1481. 

LeMagueres, P., Im, H., Dvorak, A., Strych, U., Benedik, M., Briggs, J., and Krause, K.L. (2003) Crystal structure at 1.45 Å resolution of alanine racemase from a pathogenic bacterium, Pseudomonas aeruginosa, contains both internal and external aldimine forms. Biochemistry. 42(50);14752-61.


Kim, M., Ulrich, S., Krause, K.L., Benedik, M., and Kohn, H. (2003) Evaluation of Amino-substituted Heterocyclic Derivatives as Alanine Racemase Inhibitors. Medicinal Chemistry Research. 12(3);130-138.


Krause, K.L. (2003) Nanotechnology Conference and Trade Show. Structure-aided drug design. Idrugs. 6(4);309-311.


Kim, M., Strych, U., Krause, K.L., Benedik, M., and Kohn, H. (2003) N(2)-substituted D,L-cycloserine derivatives: synthesis and evaluation as alanine racemase inhibitors. The Journal of Antibiotics. 56;160-168.


Liu, L., Im, H., Cegielski, M., LeMagueres, P., Schultz, L., Krause, K.L., and Hastings, J. (2003) Characterization and Crystallization of Active Domains of a Novel Luciferase from a Marine Dinoflagellate. Acta Crystalogr D Biol Crystallogr. 59;761-764.

Vidakovic, M., Crossnoe, C., Neidre, C., Kim, K., Krause, K.L., and Germanas, J. (2003) Reactivity of reduced [2Fe-2S] ferredoxins parallels host susceptibility towards nitroimidazoles. Antimicrob Agents and Chemother. 47(1);302-308.

Krause, K.L., and Miller, M. (2002) A new engine for cleaving nucleic acid. In: Structures and Mechanisms: From Ashes to Enzymes. Eaton, G., Wiley, D., and Jardetzky, O., eds. ACS Symposium Series Volume 827. Oxford University Press. pp. 270-293.


Crossnoe, C., Germanas, J., LeMagueres, P., Mustata, G., and Krause, K.L. (2002) The Crystal Structure of Trichomonas vaginalis Ferredoxin Provides Insight into Metronidazole Activation. J. Mol. Biol. 318;503-518.


Bussiere, D., and Krause, K.L. (2002) Biotechnology and Drug Discovery: Two years into the new millennium. In: Technical Proceedings of the Second International Conference on Computational Nanoscience and Nanotechnology. Laudon, M., and Romanowicz, B., eds. Computational Publications. Cambridge, MA. pp. 44-49.


Musher, D., Dowell, M., Shortridge, V., Flamm, R., Jorgensen, J., Magueres, P., and Krause, K.L. (2002) Emergence of macrolide resistance during treatment of pneumococcal pneumonia with azithromycin. New England J. Med. 346;630-631.

Strych, U., Penland, R., Jimenez, M., Krause, K.L., and Benedik, M. (2001) Characterization of the alanine racemases from two Mycobacteria. FEMS Microbiology Letters. 196;93-98.


Krause, K.L., and Miller, M. (2001) Using Electrostatics to Define the Active Site of Serratia Endonuclease. In: Methods in Molecular Biology: Nuclease Methods and Protocols. Eds. C. Schein, Humana Press, Totowa, NJ. 160;249-261.

Strych, U., Huang, H., Krause, K.L., and Benedik, M. (2000) Characterization of the Alanine Racemases from Pseudomonas aeruginosa PAO1. Current Microbiology. 41;290-294.