Copy number

Normally we inherit one copy of gene from each of our parents. However, some genes important in immune system function have either been duplicated or deleted in our genomes. This means we could inherit anywhere from zero to 5-10 copies of a particular gene. If this happens then it is possible that our chances of getting autoimmune diseases, such as rheumatoid arthritis and inflammatory bowel disease are affected.

Our publications on gene copy number

Bentley RB, Pearson J, Gearry RB, Barclay ML, McKinney C, Merriman TR, Roberts RL (2010) Association of higher DEFB4 copy number with Crohn’s disease. Am J Gastroenterol. 105:354-9.  PubMed

McKinney C, Fanciulli M, Merriman M, Phipps-Green A, Alizadeh B, Koeleman B, Dalbeth N, Gow P, Harrison A, Highton J, Jones P, Stamp L, Steer S, Barrera P, Coenen M, Franke B, van Riel P, Vyse T, Aitman T, Radstake T, Merriman TR (2010) Association of variation in Fc Gamma Receptor 3B (FCGR3B) gene copy number with rheumatoid arthritis in Caucasian samples Ann Rheum Dis May 14 [ePub ahead of print]PubMed

McKinney C, Merriman ME, Chapman PT, Gow PJ, Harrison AA, Highton J, Jones PBB, McLean L, O’Donnell JL, Pokorny V, Spellerberg M, Stamp LK, Willis J, Steer S, Merriman TR (2008) Evidence for an influence of chemokine ligand 3-like 1 (CCL3L1) gene copy number on susceptibility to rheumatoid arthritis. Ann Rheum Dis 67:409-13.PubMed